A Single-Administration Microneedle Skin Patch for Multi-Burst Release of Vaccine against SARS-CoV-2.

The necessity for multiple injections and cold-chain storage has contributed to suboptimal vaccine utilization, especially in pandemic situations. Thermally-stable and single-administration vaccines hold a great potential to revolutionize the global immunization process. Here, a new approach to thermally stabilize protein-based antigens is presented and a new high-throughput antigen-loading process is devised to create a single-administration, pulsatile-release microneedle (MN) patch which can deliver a recombinant SARS-CoV-2 S1-RBD protein-a model for the COVID-19 vaccine. Nearly 100% of the protein antigen could be stabilized at temperatures up to 100 °C for at least 1 h and at an average human body temperature (37 °C) for up to 4 months. Arrays of the stabilized S1-RBD formulations can be loaded into the MN shells via a single-alignment assembly step. The fabricated MNs are administered at a single time into the skin of rats and induce antibody response which could neutralize authentic SARS-CoV-2 viruses, providing similar immunogenic effect to that induced by multiple bolus injections of the same antigen stored in conventional cold-chain conditions. The MN system presented herein could offer the key solution to global immunization campaigns by avoiding low patient compliance, the requirement for cold-chain storage, and the need for multiple booster injections.

A qualitative study on stress, coping strategies and feasibility of music intervention among women with cancer receiving chemotherapy during COVID-19 pandemic in Vietnam.

Breast and gynaecological cancer (BGC) patients receiving chemotherapy may experience high levels of stress during the COVID-19 pandemic. Music interventions may be effective in lowering their stress levels. This study explored stressors, coping strategies, and the feasibility of music interventions among BGC patients in Vietnam. An exploratory qualitative study with individual face-to-face semi-structured interviews was conducted. A convenience sample of BGC patients receiving chemotherapy was recruited from the oncology centre of a public hospital in Vietnam. Twenty patients were interviewed with open-ended questions developed based on the transactional model of stress and coping to explore stress-causing factors and coping strategies and based on guidelines for music therapy practice to explore their music preferences and perceptions. Field notes and interview transcripts were analysed following the qualitative content analysis approach. Two stressor themes were identified: undesirable experiences during treatment and patients' inability to fulfil their own roles and responsibilities. Our findings revealed a new coping strategy-self-realisation of responsibilities towards the family-that is not listed in the transactional model of stress and coping. Future psychological interventions for stress management among BGC patients should focus on raising the patients' awareness of their values and responsibilities towards their families. Three categories of preferred music genres for stress reduction were identified: religious, softly melodic, and revolutionary music. The patients were aware of the positive effects of music and had different musical preferences. This study also explored the acceptance of music interventions and facilitators and barriers to implementing them among BGC patients in Vietnam. The findings suggest that before implementing music interventions, the musical preferences, religions, and beliefs of each individual should be considered to achieve desirable results. Music interventions for BGC patients receiving chemotherapy in Vietnam are feasible. Further intervention studies are needed to evaluate their effectiveness.

Detecting Exams Fraud Using Transfer Learning and Fine-Tuning for ResNet50

Online examinations gradually become popular due to Covid 19 pandemic. Environmentally friendly, saving money, and convenient,.. are some of the advantages when taking exams online. Besides its major benefits, online examinations also have some serious adversities, especially integrity and cheating. There are some existing proctoring systems that support anti-cheating, but most of them have a low probability of predicting fraud based on students' gestures and posture. As a result, our article will introduce an online examination called ExamEdu that supports integrity, in which the accuracy of detecting cheating behaviors is 96.09% using transfer learning and fine-tuning for ResNet50 Convolutional Neural Network. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

Online Project Management Service adoption intention: An integration of Technology Acceptance Model and Task-Technology Fit theory

The COVID-19 pandemic has accelerated the speed of digital transformation. These new developments will either remain the same or evolve as individuals realize that digital may help them handle various problems today and in the future. Businesses realize that utilizing an online project management service (OPMS) may help them save money and make project management more accessible;as a result, demand for this service is increasing. To better assess OPMS adoption intentions, this research combined the Technology Acceptance Model (TAM) with Task-Technology Fit theory (TTF). An online poll was performed to gather quantitative data from 247 businesses that utilize OPMS for their business processes. This study affirmed the TAM in OPMS, as all connections between perceived ease of use, perceived usefulness, attitude toward OPMS, and OPMS adoption intention are supported. Furthermore, the task-technology fit of OPMS has a significant effect on perceived usefulness and ease of use. © 2021 IEEE.

Effects of an Online Community Intervention on Taiwanese Sugar Intake Behavior

Sugar intake has increasingly been a threat because of its association with chronic diseases such as diabetes. During the ongoing Covid-19 pandemic, people have stayed indoors with minimal activities, leading to unhealthy eating habits and weight gain. However, through health-promotion education, these threats could be managed. This study focused on an online heath nutrition program for sugar reduction, with an aim of developing an online training program for reducing sugar intake. Data were collected from 100 participants belonging to a Facebook community in Taiwan. They performed activities guided by research's daily lesson plans for a maximum of 10 minutes per day for three weeks. Online questionnaires were used for the pretest and posttest. Findings revealed significant differences in health knowledge (t(99) = -8.27, p < .001), attitude (t(99) = -8.98, p < .001), self-efficacy (t(99) = -10.14, p < .001), and perceived healthy behavior (t(99) = -12.40, p < .001), with their posttest scores being higher than their pretest scores. These findings imply that online training on Facebook is an effective educational tool during the Covid-19 pandemic. Therefore, this study contributes to behavioral science knowledge by revealing Facebook as a facilitating and training platform for promoting healthy behavior, and access to information on reduction of sugar intake during pandemic. Furthermore, these findings could be used as empirical evidence of the possibility of implementing online nutrition programs for the teaching and training of online communities.